Functional dependencies between genes are a defining characteristic of gene networks
underlying quantitative traits. However, recent studies show that the proportion of the genetic …

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite
the biological plausibility that nonlinear molecular interactions underpin the genotype …

Great progress has been made in genetic dissection of quantitative trait variation during the
past two decades, but many studies still reveal only a small fraction of quantitative trait loci …

Gene expression data has been used in lieu of phenotype in both classical and quantitative
genetic settings. These two disciplines have separate approaches to measuring and …

Modern genomewide association studies are characterized by the problem of “missing
heritability.” Epistasis, or genetic interaction, has been suggested as a possible explanation …

The importance of epistasis—or statistical interactions between genetic variants—to the
development of complex disease in humans has been controversial. Genome-wide …

Although research effort is being expended into determining the importance of epistasis and
epistatic variance for complex traits, there is considerable controversy about their …

Biochemical and regulatory interactions central to biological networks are expected to cause
extensive genetic interactions or epistasis affecting the heritability of complex traits and the …

Understanding the effect of genetic sequence variation on phenotype is a major challenge
that lies at the heart of genetics. We developed GOLPH (GenOmic Linkage to PHenotype), a …

Epistasis between mutations in two genes is thought to reflect an interdependence of their
functions. While sometimes epistasis is predictable using mechanistic models, its roots …