Tuberculosis (TB) kills more individuals each year than any other single pathogen and a
more effective vaccine is critical for the global control of the disease. Although there has …

Despite the widespread use of standardised drug regimens, advanced diagnostics, and
Mycobacterium bovis Bacille-Calmette-Guérin (BCG) vaccines, the global tuberculosis (TB) …

Improved vaccines capable of promoting long-term cellular immunity are urgently required
for a number of diseases that remain global health problems. In the present study, we …

The purpose of vaccination is to establish a stable population of long lived memory T cells.
In the context of tuberculosis, the BCG vaccine has been widely used for well over 60 years …

Tuberculosis (TB) is a serious disease around the world. Bacillus Calmette–Guérin (BCG) is
the only TB vaccine licensed for use in human beings, and is effective in protecting infants …

Despite the generation of Mycobacterium tuberculosis-specific T cell immune responses
during the course of infection, only 5 to 10% of exposed individuals develop active disease …

Tuberculosis (TB) is a serious infectious disease caused by infection with Mycobacterium
tuberculosis, and kills more people annually than any other single infectious agent. Although …

Vaccine development against tuberculosis (TB) is based on the induction of adaptive
immune responses endowed with long-term memory against mycobacterial antigens …

Accumulating evidence indicates that inflammatory signals required for maximizing effector
T cell generation have opposing effects on the development of memory T cell precursors …

The bacterium Mycobacterium tuberculosis remains one of the world's most successful
pathogens, a situation that is aggravated by the fact that the existing vaccine, Mycobacterium …