Heterogeneity in tuberculosis

AM Cadena, SM Fortune, JAL Flynn - Nature Reviews Immunology, 2017 - nature.com
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …

The end of the binary era: revisiting the spectrum of tuberculosis

PL Lin, JAL Flynn - The Journal of Immunology, 2018 - journals.aai.org
Human Mycobacterium tuberculosis infection was thought to result in either active
symptomatic tuberculosis (TB) or latent asymptomatic infection. It is now clear that this binary …

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

CE Barry 3rd, HI Boshoff, V Dartois, T Dick… - Nature Reviews …, 2009 - nature.com
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …

The immune landscape in tuberculosis reveals populations linked to disease and latency

E Esaulova, S Das, DK Singh, JA Choreno-Parra… - Cell host & …, 2021 - cell.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …

Understanding latent tuberculosis: a moving target

PL Lin, JAL Flynn - The Journal of Immunology, 2010 - journals.aai.org
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

A Lenaerts, CE Barry III, V Dartois - Immunological reviews, 2015 - Wiley Online Library
Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …

The past and future of tuberculosis research

I Comas, S Gagneux - PLoS pathogens, 2009 - journals.plos.org
Renewed efforts in tuberculosis (TB) research have led to important new insights into the
biology and epidemiology of this devastating disease. Yet, in the face of the modern …

Immune correlates of tuberculosis disease and risk translate across species

M Ahmed, S Thirunavukkarasu, BA Rosa… - Science translational …, 2020 - science.org
One quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB). Although most infected individuals successfully control …

Latent tuberculosis infection–revisiting and revising concepts

P Salgame, C Geadas, L Collins, E Jones-López… - Tuberculosis, 2015 - Elsevier
Host-and pathogen-specific factors interplay with the environment in a complex fashion to
determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one …

The knowns and unknowns of latent Mycobacterium tuberculosis infection

WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …