Heterogeneity in tuberculosis
AM Cadena, SM Fortune, JAL Flynn - Nature Reviews Immunology, 2017 - nature.com
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), results
in a range of clinical presentations in humans. Most infections manifest as a clinically …
in a range of clinical presentations in humans. Most infections manifest as a clinically …
The end of the binary era: revisiting the spectrum of tuberculosis
PL Lin, JAL Flynn - The Journal of Immunology, 2018 - journals.aai.org
Human Mycobacterium tuberculosis infection was thought to result in either active
symptomatic tuberculosis (TB) or latent asymptomatic infection. It is now clear that this binary …
symptomatic tuberculosis (TB) or latent asymptomatic infection. It is now clear that this binary …
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Immunological tests provide evidence of latent tuberculosis in one third of the global
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
population, which corresponds to more than two billion individuals. Latent tuberculosis is …
The immune landscape in tuberculosis reveals populations linked to disease and latency
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects
approximately one-fourth of the world's population. The immune mechanisms that govern …
approximately one-fourth of the world's population. The immune mechanisms that govern …
Understanding latent tuberculosis: a moving target
PL Lin, JAL Flynn - The Journal of Immunology, 2010 - journals.aai.org
Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …
Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection …
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
A Lenaerts, CE Barry III, V Dartois - Immunological reviews, 2015 - Wiley Online Library
Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …
types and fates of pulmonary lesions that form following infection by M ycobacterium …
The past and future of tuberculosis research
Renewed efforts in tuberculosis (TB) research have led to important new insights into the
biology and epidemiology of this devastating disease. Yet, in the face of the modern …
biology and epidemiology of this devastating disease. Yet, in the face of the modern …
Immune correlates of tuberculosis disease and risk translate across species
M Ahmed, S Thirunavukkarasu, BA Rosa… - Science translational …, 2020 - science.org
One quarter of the world's population is infected with Mycobacterium tuberculosis (Mtb), the
causative agent of tuberculosis (TB). Although most infected individuals successfully control …
causative agent of tuberculosis (TB). Although most infected individuals successfully control …
Latent tuberculosis infection–revisiting and revising concepts
P Salgame, C Geadas, L Collins, E Jones-López… - Tuberculosis, 2015 - Elsevier
Host-and pathogen-specific factors interplay with the environment in a complex fashion to
determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one …
determine the outcome of infection with Mycobacterium tuberculosis (Mtb), resulting in one …
The knowns and unknowns of latent Mycobacterium tuberculosis infection
WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …