During early development, both genome‐wide epigenetic reprogramming and metabolic
remodeling are hallmark changes of normal embryogenesis. However, little is known about …

Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic
transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated …

Testis is the primary organ of the male reproductive tract in mammals that plays a substantial
role in spermatogenesis. Improvement of our knowledge regarding the molecular …

In a previous study, we found miR-10b to be more abundant in a conditioned culture
medium of degenerate embryos compared to that of blastocysts. Here, we show that miR …

N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of
somatic cells into induced pluripotent stem cells. However, the role of m6A methylation in …

Folic acid is vital for DNA synthesis and methylations through one-carbon (C1) metabolism.
Thus, it is essential for cell division during embryonic development. Although the oocytes …

Parthenogenesis activation (PA), as an important artificial breeding method, can stably
preserve the dominant genotype of a species. However, the delayed development of PA …

Maternal B-vitamin status at conception can affect fertility and the health of offspring. This
study details transcript expression for genes encoding key enzymes in the linked …

Adenosylhomocysteinase (AHCY), a key enzyme in the methionine cycle, is essential for the
development of embryos and the maintenance of mouse embryonic stem cells (mESCs) …

Methionine adenosyltransferase (MAT) is a critical biological enzyme and that can catalyze
L-met and ATP to form S-adenosylmethionine (SAM), which is acted as a biological methyl …