Abnormal uptake or metabolism of folate increases risk of human pregnancy complications,
though the mechanism is unclear. Here, we explore how defective folate metabolism …

Initially perceived simply as an ATP producer, mitochondria also participate in a wide range
of other cellular functions. Mitochondrial communication with the nucleus, as well as …

One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of
purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding …

Major zygotic genome activation (ZGA) occurs at the late 2‐cell stage and involves the
activation of thousands of genes, supporting early embryonic development. The reasons …

Dietary intake in early lactating cows is outmatched by milk production. These cows
experience a negative energy balance, resulting in a distinct blood metabolism and poor …

Background/Aims: Aberrantly high levels of H3K4me3, caused by incomplete epigenetic
reprogramming, likely cause a low efficiency of somatic cell nuclear transfer (SCNT). Smal …

Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites.
However, metabolic features, and their impact on epigenetic remodeling during mammalian …

Although noncancerous immortalized cell lines have been developed by introducing genes
into human and murine somatic cells, such cell lines have not been available in large …

DNMT3A participates in de novo methylation, yet its impact on the proliferation of testicular
Sertoli cells remains unclear. Development-specific methylation has been proven to be …

Abstract K (lysine) acetyltransferase 8 (KAT8), an acetyltransferase that specifically
catalyzes histone H4 lysine 16 acetylation, is critical for key biological processes including …