Background Nonruminant male and female offspring respond differently to gestational
nutrition, with placenta contributing to the underlying mechanisms. However, similar data are …

Ten–eleven translocation 3 (TET 3) mediates active DNA demethylation of paternal
genomes during mouse embryonic development. However, the mechanism of DNA …

The potential regulatory role of N6-methyladenosine (m6A), the most prominent mRNA
modification in eukaryotes, has recently been identified in mammals, plants, and yeast …

Epigenetic modifications, including DNA methylation and histone modifications, are
reprogrammed considerably following fertilization during mammalian early embryonic …

Simple Summary Wilms' tumor 1-associating protein (WTAP) is a key subunit of the N6-
methyl-adenosine (m6A) methyltransferase complex during porcine early embryo …

Abstract Lysine-specific demethylase 1 (LSD1) stands as the pioneering histone
demethylase uncovered, proficient in demethylating H3K4me1/2 and H3K9me1/2, thereby …

DNA methylation as an important, essential epigenetic modification is critical for the
successful development of mammalian embryos. In recent years, the important role of …

Maternal factors are required for oocyte maturation and embryo development. To better
understand the role of DNA methyltransferase 1 (Dnmt1) in oocyte maturation and embryo …

Spermatogenesis is a continual process that occurs in the testes, in which diploid
spermatogonial stem cells (SSCs) differentiate and generate haploid spermatozoa. This …

Successful early embryo development requires the correct reprogramming and configuration
of gene networks by the timely and faithful execution of zygotic genome activation (ZGA) …