Unleashing the efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma: factors, strategies, and ongoing trials

J Yu, M Li, B Ren, L Cheng, X Wang, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a prevalent primary liver cancer, representing
approximately 85% of cases. The diagnosis is often made in the middle and late stages …

Current landscape of immune checkpoint inhibitor therapy for hepatocellular carcinoma

N Machairas, DI Tsilimigras, TM Pawlik - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is the most common primary hepatic
malignancy, with increasing incidence over the past several decades. The majority of …

Immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Z Akbulut, B Aru, F Aydın… - Frontiers in …, 2024 - frontiersin.org
Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

Immune checkpoint inhibitors for advanced hepatocellular carcinoma: Monotherapies and combined therapies

T Ouyang, X Kan, C Zheng - Frontiers in oncology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is an important cause of cancer death and is considered
the 3rd most lethal around the world. Hepatectomy, liver transplantation, and ablation …

[HTML][HTML] Treatment of advanced hepatocellular carcinoma: immunotherapy from checkpoint blockade to potential of cellular treatment

EHL Siu, AWH Chan, CCN Chong… - Translational …, 2018 - ncbi.nlm.nih.gov
The absence of potent therapeutic option accounts for the dismal prognosis of advanced
hepatocellular carcinoma (HCC) with high mortality and recurrence rate. For a decade …

Lessons from immune checkpoint inhibitor trials in hepatocellular carcinoma

R Mohr, F Jost-Brinkmann, B Özdirik… - Frontiers in …, 2021 - frontiersin.org
The implementation of immune checkpoint inhibitors (ICI) into the clinical management of
different malignancies has largely changed our understanding of cancer treatment. After …

First-line immune checkpoint inhibitor-based combinations in unresectable hepatocellular carcinoma: current management and future challenges

A Rizzo, AD Ricci, G Gadaleta-Caldarola… - Expert Review of …, 2021 - Taylor & Francis
Introduction Immunotherapy has recently taken on an extremely important role in medical
oncology, as first-or later-line treatment in several tumor types, and recent years have seen …

Cure the incurable? Recent breakthroughs in immune checkpoint blockade for hepatocellular carcinoma

PY Chu, SH Chan - Cancers, 2021 - mdpi.com
Simple Summary Liver cancer is one of the most devastating human malignancies
worldwide, especially in Asia, where over 70% of new cases are diagnosed. Most liver …

Immunotherapy updates in advanced hepatocellular carcinoma

A Singh, RJ Beechinor, JC Huynh, D Li, F Dayyani… - Cancers, 2021 - mdpi.com
Simple Summary Advanced hepatocellular carcinoma (HCC) carries a grim prognosis,
which has historically been compounded by a lack of available systemic therapies …

Combination of molecularly targeted therapies and immune checkpoint inhibitors in the new era of unresectable hepatocellular carcinoma treatment

ZL Liu, JH Liu, D Staiculescu… - Therapeutic Advances in …, 2021 - journals.sagepub.com
Multikinase inhibitors (MKIs) have been the only first-line treatment for advanced
hepatocellular carcinoma (HCC) for more than a decade, until the approval of immune …