Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …

Septic shock is initiated by a systemic inflammatory response to microbial infection that
frequently leads to impaired perfusion and multiple organ failure. Because of its high risk of …

Lipopolysaccharide (LPS) sensing in the cytosol by the noncanonical inflammasome leads
to pyroptosis and NLRP3 inflammasome activation. This mechanism may be more critical for …

Endotoxin, more accurately referred to as lipopolysaccharide (LPS), is recognized as the
most potent microbial mediator implicated in the pathogenesis of sepsis and septic shock …

Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most
Gram-negative bacteria and has diverse immunostimulatory and procoagulant effects. Even …

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options
and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in …

Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

Septic shock is an increasingly important clinical condition, characterized by systemic
hypotension, ischemia, and ultimately organ failure. In Gram negative infection, the bacterial …

The term sepsis describes a potentially lethal clinical condition that develops as a result of a
dysregulated host response to bacterial infection. The most common bacterial component …

Sepsis remains one of the most common and lethal conditions globally. Currently, no
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …