The lipopolysaccharide (LPS)-binding protein (LBP) has a concentration-dependent dual
role in the pathogenesis of gram-negative sepsis: low concentrations of LBP enhance the …

Patients with sepsis have a marked defect in neutrophil migration. Here we identify a key
role of Toll-like receptor 2 (TLR2) in the regulation of neutrophil migration and resistance …

The endothelium forms a vast network that dynamically regulates vascular barrier function,
coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Lipopolysaccharide (LPS [endotoxin]) is the principal component of the outer membrane of
Gram-negative bacteria. Recent studies have elucidated how LPS is recognized by …

Inflammation is a body's protective mechanism to eliminate invading pathogens and cellular
damaging signals. The inflammatory response consists of two main consecutive steps—a …

Highlights•MD-2 and CD14 regulate the transport and signaling functions of TLR4.•LPS-
induced CD14 aggregation modulates PIP5K activity to promote myddosome signaling …

The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …

Cell death and release of proinflammatory mediators contribute to mortality during sepsis.
Specifically, caspase-11–dependent cell death contributes to pathology and decreases in …

Inflammasome activation and subsequent pyroptosis are critical defense mechanisms
against microbes. However, overactivation of inflammasome leads to death of the host …