Uncovering the genetic architecture of multiple sclerosis

F Esposito, PL De Jager - CONTINUUM: Lifelong Learning in …, 2010 - journals.lww.com
Multiple sclerosis (MS) is a disease in which genetic, environmental, and stochastic factors
interact to trigger an inflammatory disease of the CNS that also has a neurodegenerative …

Monocytes and monocyte-derived antigen-presenting cells have distinct gene signatures in experimental model of multiple sclerosis

KL Monaghan, W Zheng, G Hu, ECK Wan - Frontiers in immunology, 2019 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease mediated by a complex interaction
between the autoreactive lymphocytes and the effector myeloid cells within the central …

Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course

E Gil-Varea, E Urcelay, C Vilariño-Güell… - Journal of …, 2018 - Springer
Background It remains unclear whether disease course in multiple sclerosis (MS) is
influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated …

Modeling the heterogeneity of multiple sclerosis in animals

SB Simmons, ER Pierson, SY Lee, JM Goverman - Trends in immunology, 2013 - cell.com
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS) manifested with varying clinical course, pathology, and inflammatory patterns …

Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes

Q Ma, H Shams, A Didonna, SE Baranzini… - Communications …, 2023 - nature.com
Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS)
susceptibility variants. Despite this notable progress, understanding the biological context of …

Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis

LES deLuca, NB Pikor, J O'Leary… - The Journal of …, 2010 - journals.aai.org
Experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis
that is executed in animals by immunization with myelin Ag in adjuvant. The SJL/J …

The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use

D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

Not all roads lead to the immune system: The genetic basis of multiple sclerosis severity implicates central nervous system and mitochondrial involvement

VG Jokubaitis, O Ibrahim, J Stankovich, P Kleinova… - MedRxiv, 2022 - medrxiv.org
Multiple sclerosis (MS) is a leading cause of neurological disability in adults. Heterogeneity
in MS clinical presentation has posed a major challenge for identifying genetic variants …

Alternative splicing and transcriptome profiling of experimental autoimmune encephalomyelitis using genome-wide exon arrays

A Gillett, K Maratou, C Fewings, RA Harris, M Jagodic… - PloS one, 2009 - journals.plos.org
Background Multiple Sclerosis (MS) is a chronic inflammatory disease causing
demyelination and nerve loss in the central nervous system. Experimental autoimmune …

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

B Bonaldo, A Casile, F Montarolo… - JoVE (Journal of Visualized …, 2023 - jove.com
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease affecting the central
nervous system (CNS). It is characterized by different prevalence in the sexes, affecting …