Recent advances in mouse genetics have identified molecular changes that are critical for
melanocyte maturation and differentiation. This review briefly summarizes the current …

The acquisition of invasive behaviour is the key transition in the progression of benign
melanocyte hyperplasia to life threatening melanoma. Understanding this transition and the …

Melanocytes (Mc) and their progenitors melanoblasts (Mb) are derived from the neural crest
and migrate along the dorsolateral pathway to colonize the dermis, the epidermis, and finally …

Melanoma development not only involves genetic and epigenetic changes that take place
within the cell, but also involves processes determined collectively by micro-environmental …

In the vertebrate embryo, melanocytes arise from the neural crest, migrate to and colonize
the basal layer within the skin and skin appendages. Post-migratory melanocytes are …

In human epidermis, functional symbiosis requires homeostatic balance between
keratinocytes and melanocytes. Compelling evidence from co-culture studies demonstrated …

Endothelin (Edn) signaling via the G‐coupled, Edn receptor type B (Ednrb) is essential for
the development of melanocytes from the neural crest (NC) and has been associated with …

Melanoma is a malignant tumor of melanocytes that can spread to other organs of the body,
resulting in severe and/or lethal malignancies. Melanocytes are pigment-producing cells …

Melanocytes are pigment‐producing cells in the skin of humans and other vertebrates. A
number of genes involved in melanocyte development and vertebrate pigmentation have …

The enormous variety of pigmentation phenotypes in nature reflects a series of remarkable
events that begin in the neural crest and end with the manufacture and distribution of …