Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective
adaptive CD8+ T cell immune responses. In addition to costimulatory signals, B7/CD28 …

Hepatitis C virus (HCV) infection is a major global health problem. Hepatic expression of
immune costimulatory signaling molecules (eg, B7) is known to be associated with ongoing …

Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure
and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia …

CD4 T‐cell function is crucial for the eradication of HCV, and insufficient function is observed
in chronic carriers. The monitoring of T‐cell responses is complicated by the scarcity of …

The lymphocytic CD81 molecule, capable of modulating type-1/-2 T-helper responses and
serving as a putative receptor for hepatitis C virus (HCV), might influence the outcome of anti …

Costimuli provide supplementary signals required by naive T cells to become fully activated
upon Ag encounter. Tetraspanins are a large family of transmembrane proteins that can …

Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation evolving to an overt lymphoma. Recently, CD81 was identified as an …

Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …

Abstract Interleukin‐7 (IL‐7) is required for the establishment and maintenance of memory
CD4+ and CD8+ T lymphocytes, and cells lacking IL‐7Rα (CD127) demonstrate impaired IL …

Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease in the
Western world affecting 1.8% of the American population and 170 million people worldwide …