Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …

Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the
synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional …

Chemokines are chemoattractant cytokines that direct the migration of leukocytes, and are
induced by inflammatory cytokines, growth factors and pathogenic stimuli (1). Chemokines …

CeC motif chemokines, including CCL2, CCL7, and CCL12, affect cells that express the
CeC chemokine receptor type 2, CCR2, a seven-transmembrane domain G-protein coupled …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the unresolved
synovial inflammation for tissues‐destructive consequence, which remains one of significant …

Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

The ingress of leukocytes into sites of inflammation is crucial for the pathogenesis of arthritis
and other inflammatory conditions. Chemokines, their receptors and cellular adhesion …

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

The efficiency of drug research and development has paradoxically declined over the last
decades despite major scientific and technological advances, promoting new cost-effective …

Rheumatoid arthritis (RA) is a systemic, autoimmune disease that affects joints and extra-
articular structures. In the last decade, the management of this chronic disease has …