Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis
(RA), together with the availability of new therapies, has changed the way we think about …

The resolution of inflammation is now known to be an active process, armed with a multitude
of mediators both lipid and protein in nature. Melanocortins are peptides endowed with …

Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to
heightened autoimmune response at the articular sites. Worldwide annual incidence and …

Germinal center (GC) reaction greatly contributes to the humoral immune response, which
begins in lymph nodes or other secondary lymphoid organs after follicular B cells are …

The intense pursuit of novel therapies in rheumatoid arthritis has provided physicians with
an assorted set of biologic drugs to treat patients with moderate to severe disease activity …

Background Blockade of granulocyte macrophage colony-stimulating factor (GM-CSF) and
its receptor (GM-CSFRα) is being successfully tested in trials in rheumatoid arthritis (RA) …

Rheumatoid arthritis (RA) is an autoimmune disorder that is slow progressive destruction of
the joints and is caused by autoantibodies that target a variety of organs thereby leading to …

Monocytes/macrophages play a central role in chronic inflammatory disorders, including
rheumatoid arthritis (RA). Activation of these cells results in the production of various …

Evidence suggests that uncontrolled immune system responses and their components play
a significant role in developing rheumatoid arthritis (RA), which is considered an …

Over the past few decades, understanding of the pathogenesis of rheumatoid arthritis (RA)
has improved substantially. Insights into the cellular and molecular mechanisms involved in …