White matter injury in the premature infant leads to motor and more commonly behavioral
and cognitive problems that are a tremendous burden to society. While there has been much …

Owing to improved survival rates of premature newborns, the number of very low birth
weight infants is rising. Preterm infants display a greater propensity for brain injury caused …

Despite the advances in neonatal intensive care, the preterm brain remains vulnerable to
white matter injury (WMI) and disruption of normal brain development (ie, dysmaturation) …

Preterm birth is an evolving challenge in neonatal health care. Despite declining mortality
rates among extremely premature neonates, morbidity rates remain very high. Currently …

Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-
OLs), is the most common form of injury to the preterm brain and is associated with a high …

Children surviving preterm birth have a high risk of disability, particularly cognitive and
learning problems. There is extensive clinical and experimental evidence that disability is …

With advances in neonatal care, preterm neonates are surviving with an evolving
constellation of motor and cognitive disabilities that appear to be related to widespread …

Periventricular white matter injury, specifically cystic periventricular leukomalacia (PVL) and
ipsilateral hemorrhage into white matter associated with periventricular-intraventricular …

The human preterm brain is particularly susceptible to cerebral white matter injury (WMI) that
disrupts the normal progression of developmental myelination. Advances in the care of …

A developing central nervous system is vulnerable to various insults such as infection and
ischemia. While increased understanding of the dynamic nature of brain development …