Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant
immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of …

Endothelial activation contributes to the development of vascular inflammation and
subsequent vascular diseases, particularly atherosclerosis. AGGF1, a new member of …

Angiogenic factor with G-patch and FHA domain 1 (AGGF1) is a novel angiogenic factor that
was first described in Klippel-Trenaunay syndrome, a congenital vascular disease …

Objective: Angiogenic factor AGGF1 (angiogenic factor with G-patch and FHA [Forkhead-
associated] domain 1) promotes angiogenesis as potently as VEGFA (vascular endothelial …

Objective To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF
binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic …

Angiogenic factor AGGF1 (AngioGenic factor with G-patch and FHA (Forkhead-Associated)
domain 1) blocks neointimal formation (formation of a new or thickened layer of arterial …

Systemic sclerosis (SSc) is an autoimmune disease mainly characterized by persistent
inflammation and fibrosis. The receptor tyrosine kinase (RTK) signal pathway plays an …

Objective—Phenotypic modulation of vascular smooth muscle cells represents a hallmark
event in vascular injury. The underlying mechanism is not completely sorted out. We …

AGGF1 encodes the angiogenic factor with G-patch and FHA (forkhead associated) domain
protein, which has been shown to be involved in multiple vascular morphogenesis …

Objective Transforming growth factor β superfamily members are involved in the
pathogenesis of systemic sclerosis (SSc). Growth differentiation factor 15 (GDF‐15) is a …