Dysfunction of hair follicle mesenchymal progenitors contributes to age-associated hair loss
Skin aging is accompanied by hair loss due to impairments in hair follicle (HF) epithelial
progenitor cells and their mesenchymal niche. This inductive mesenchyme, called dermal …
progenitor cells and their mesenchymal niche. This inductive mesenchyme, called dermal …
[HTML][HTML] Transcriptional profiling of the adult hair follicle mesenchyme reveals R-spondin as a novel regulator of dermal progenitor function
The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial
stem cells and neighboring mesenchyme. Recent work described the existence of HF …
stem cells and neighboring mesenchyme. Recent work described the existence of HF …
[HTML][HTML] Aging of hair follicle stem cells and their niches
Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest
throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue …
throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue …
The aging skin microenvironment dictates stem cell behavior
Aging manifests with architectural alteration and functional decline of multiple organs
throughout an organism. In mammals, aged skin is accompanied by a marked reduction in …
throughout an organism. In mammals, aged skin is accompanied by a marked reduction in …
Signaling networks among stem cell precursors, transit-amplifying progenitors, and their niche in developing hair follicles
The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study
stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla …
stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla …
Stem cell‐intrinsic mechanisms regulating adult hair follicle homeostasis
SA Lee, KN Li, T Tumbar - Experimental dermatology, 2021 - Wiley Online Library
Adult hair follicle stem cells (HFSCs) undergo dynamic and periodic molecular changes in
their cellular states throughout the hair homeostatic cycle. These states are tightly regulated …
their cellular states throughout the hair homeostatic cycle. These states are tightly regulated …
Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type
The dermal papilla (DP) provide instructive signals required to activate epithelial progenitors
and initiate hair follicle regeneration. DP cell numbers fluctuate over the hair cycle, and hair …
and initiate hair follicle regeneration. DP cell numbers fluctuate over the hair cycle, and hair …
High‐resolution single‐cell transcriptomics reveals heterogeneity of self‐renewing hair follicle stem cells
G Chovatiya, S Ghuwalewala, LD Walter… - Experimental …, 2021 - Wiley Online Library
Multipotent bulge stem cells (SCs) fuel the hair follicle (HF) cyclic growth during adult skin
homeostasis, but their intrinsic molecular heterogeneity is not well understood. These hair …
homeostasis, but their intrinsic molecular heterogeneity is not well understood. These hair …
[HTML][HTML] Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells
Hair follicle harbors a rich stem cell pool with mesenchymal lineage differentiation potential.
Although previous studies with rodent cells demonstrated that hair follicle sheath and papilla …
Although previous studies with rodent cells demonstrated that hair follicle sheath and papilla …
A two-step mechanism for stem cell activation during hair regeneration
Hair follicles (HFs) undergo cyclic bouts of degeneration, rest, and regeneration. During rest
(telogen), the hair germ (HG) appears as a small cell cluster between the slow-cycling bulge …
(telogen), the hair germ (HG) appears as a small cell cluster between the slow-cycling bulge …