In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …

In the search for new therapeutic alternatives for Chagas disease, a series of six aryloxy-
naphthoquinone derivatives were synthesized and evaluated in vitro against Trypanosoma …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

The available treatment for the prevention and cure of Chagas disease, caused by the
protozoan Trypanosoma cruzi, is still unsatisfactory. Thus, there is an urgent need to …

The discovery and development of essential drugs for Chagas disease is a major concern
worldwide. New substituted 1, 4-naphthoquinones were synthesized and tested against the …

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …

Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately
eight million individuals in the developing world; it is also classified as a neglected tropical …

Naphthoquinone is a heterocyclic moiety whose natural derivatives are present as bioactive
compounds in many plants and have stimulated a resurgence of interest in the past decades …