Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury
Traumatic brain injury (TBI) induces microglial activation, which can contribute to secondary
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …
tissue loss. Activation of mGluR5 reduces microglial activation and inhibits microglial …
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
Background Traumatic brain injury initiates biochemical processes that lead to secondary
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
neurodegeneration. Imaging studies suggest that tissue loss may continue for months or …
Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental …
Traumatic brain injury (TBI) causes microglial activation and related neurotoxicity that
contributes to chronic neurodegeneration and loss of neurological function. Selective …
contributes to chronic neurodegeneration and loss of neurological function. Selective …
Activation of metabotropic glutamate receptor 5 reduces the secondary brain injury after traumatic brain injury in rats
JW Wang, HD Wang, ZX Cong, XS Zhang… - Biochemical and …, 2013 - Elsevier
A wealth of evidence has shown that microglia-associated neuro-inflammation is involved in
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …
the secondary brain injury contributed to the poor outcome after traumatic brain injury (TBI) …
[HTML][HTML] The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway
T Chen, L Zhang, Y Qu, K Huo… - … journal of molecular …, 2012 - spandidos-publications.com
Group I metabotropic glutamate receptors (mGluRs) have been implicated in the
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …
pathophysiology of central nervous system injury, but the role of mGluR5 in traumatic brain …
Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain …
SA Bhat, RJ Henry, AC Blanchard… - Journal of …, 2021 - Wiley Online Library
We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM)
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …
is neuroprotective after experimental traumatic brain injury (TBI), limiting post‐traumatic …
Protective effects of mGluR5 positive modulators against traumatic neuronal injury through PKC-dependent activation of MEK/ERK pathway
T Chen, L Cao, WP Dong, P Luo, WB Liu, Y Qu… - Neurochemical …, 2012 - Springer
Several previous studies utilizing selective pharmacological antagonists have demonstrated
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …
that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for …
Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury
F Zhou, B Hongmin, Z Xiang, L Enyu - Journal of clinical neuroscience, 2003 - Elsevier
Objective Excessive release of glutamate from nerve terminals following diffuse brain injury
(DBI) is thought to contribute to neuronal calcium overload leading to calcium-mediated cell …
(DBI) is thought to contribute to neuronal calcium overload leading to calcium-mediated cell …
Activation of mGluR5 attenuates microglial activation and neuronal apoptosis in early brain injury after experimental subarachnoid hemorrhage in rats
Z Zhang, B Sun, J Liu, M Yang, D Li, J Fang… - Neurochemical …, 2015 - Springer
Activation of metabotropic glutamate receptor 5 (mGluR5) provided neuroprotection in
multiple central nervous system injury, but the roles of mGluR5 in subarachnoid hemorrhage …
multiple central nervous system injury, but the roles of mGluR5 in subarachnoid hemorrhage …
Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents
Objective Activation of metabotropic glutamate receptor 5 (mGluR5) has neuroprotective
properties in vitro and has been reported to limit postischemic lesion volume in vivo …
properties in vitro and has been reported to limit postischemic lesion volume in vivo …
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