Mirex exposure inhibits the uptake of estradiol-17β (β-D-glucuronide), taurocholate, and L-alanine into isolated rat hepatocytes

S Teo, M Vore - Toxicology and applied pharmacology, 1990 - Elsevier
The insecticides mirex and chlordecone have previously been found to suppress the biliary
excretion of a wide variety of compounds. In the present studies, the effects of mirex …

Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

M Kobayashi, H Saitoh, M Kobayashi, K Tadano… - … of Pharmacology and …, 2004 - ASPET
The onset of diarrhea after the administration of mycophenolate mofetil (MMF) is possibly
associated with the biliary excretion of its metabolite, mycophenolic acid glucuronide …

Choleretic action of diosgenin is based upon the increases in canalicular membrane fluidity and transporter activity mediating bile acid independent bile flow

A Yamaguchi, S Tazuma, H Ochi, K Chayama - Hepatology research, 2003 - Elsevier
It is known that diosgenin alters the lipid composition of hepatic plasma membranes as well
as bile lipids. We recently reported that changes in the lipid composition of the canalicular …

The effects of Kepone pretreatment on biliary excretion of xenobiotics in the male rat

LR Curtis, HM Mehendale - Toxicology and Applied Pharmacology, 1979 - Elsevier
Hepatic excretory function of Kepone (chlordecone)-preexposed (10, 50, 150 ppm in daily
ration for 15 days) male rats was examined in conjunction with hepatic mitochondrial Mg2+ …

Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats

R Xu, X Zhang, J Yang, X Liu… - … & Drug Disposition, 2012 - Wiley Online Library
The purpose of the current study was to determine whether glycyrrhizin (GL) maintains
hepatic glutathione (GSH) levels by inhibiting GSH biliary secretion in normal rats. The …

Beneficial effects of colchicine on 17α-ethynylestradiol-induced cholestasis in rats

ZX Zhou, T Wang, ZZ Jiang, J Shang, L Liu… - …, 2011 - thieme-connect.com
Colchicine (CAS 64-86-8) is considered to have a hepatoprotective effect and play a role in
biliary excretion. 17a-Ethynyl-estradiol (EE)(5 mg/kg, subcutaneously, daily, for 5 days) …

Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2

DR Johnson, SSM Habeebu… - Toxicological …, 2002 - academic.oup.com
Glutathione (GSH) is an important cellular constituent for normal liver homeostasis. Certain
drug-metabolizing enzyme inducers (ie, phenobarbital [PB] and pregnenolone-16α …

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation

J Tian, J Zhu, Y Yi, C Li, Y Zhang, Y Zhao, C Pan… - Scientific reports, 2017 - nature.com
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in
China for medicinal purposes. Currently, clinical reports of FG toxicity have not been …

Effects of phalloidin on the biliary excretion of cholephilic compounds in rats

M Ohashi, N Sano, H Takikawa - Pharmacology, 2002 - karger.com
Phalloidin is known to cause cholestasis by preventing microfilament depolymerization. In
addition, phalloidin is reported to inhibit the vesicular targeting of canalicular transporters …

[PDF][PDF] Inhibition by colchicine of biliary secretion of diethylmaleate in the rat: Evidence for microtubule‐dependent vesicular transport

M Dumont, S D'Hont, AM Durand‐Schneider… - …, 1991 - Wiley Online Library
It has been proposed that a microtubule‐dependent transport of vesicles derived from the
Golgi apparatus may play a role in biliary secretion of bile salts and other cholephilic anions …