In male rats challenged with the environmental estrogen bisphenol A, the compound is
highly glucuronidated in the liver and is excreted largely into the bile. Given that in …

Aim: Drug‐induced hyperbilirubinemia has been shown to often be derived from modulation
of the expression and activity of hepatobiliary transporters. In this study we examined the …

Silymarin, an extract from seeds of Silybum marianum, is used by 8 to 33% of patients to self-
treat chronic viral hepatitis C in the United States. Studies in humans and rodents suggest …

Male Sprague-Dawley rats were treated with mirex, po, at 0, 5, 10, and 50 mg/kg/day in 0.4
ml of corn oil for 3 days. Forty-eight hours after the last treatment, the biliary excretion of …

Fasiglifam (TAK-875), a selective G-protein–coupled receptor 40 agonist, was developed for
the treatment of type 2 diabetes mellitus; however, its development was terminated in phase …

Moxifloxacin is a novel antibacterial agent that undergoes extensive metabolism in the liver
to the glucuronide M1 and the sulfate M2, which are eliminated via the bile. To investigate …

1. The roles of multidrug resistance-associated protein (Mrp) 2 deficiency and Mrp3 up-
regulation were evaluated on the metabolism and disposition of gemfibrozil. 2. Results from …

Objectives The effect of genistein, a natural soy isoflavone, on pharmacokinetics and
intestinal toxicity, or late-onset diarrhoea, of irinotecan hydrochloride (CPT-11) was …

Purpose. To examine the presence of multiplicity for the biliary excretion of xenobiotic
conjugates, we studied the disposition of glycyrrhizin (GR), which has glucuronide within its …

Previous studies implicated P-glycoprotein (P-gp) as the major transport protein responsible
for the biliary excretion of fexofenadine (FEX). However, FEX biliary excretion was not …