Raloxifene-6-glucuronide (R6G) is a substrate of rat multidrug resistance-associated protein
2 (Mrp2), a transporter responsible for biliary excretion of organic anions. 2 …

Background Hepatocytes in zone 1 of the hepatic lobule play a role in the uptake and biliary
excretion of bile acids and organic anions under physiological conditions, and hepatocytes …

Hepatic multidrug resistance‐associated protein 2 (Mrp2) is responsible for the majority of
the biliary elimination of endogenous and exogenous substances, therefore it is important to …

In hepatic dysfunction, renal pharmacokinetic adaptation can be observed, although
information on the changes in drug exposure and the interorgan regulation of membrane …

Abstract Estradiol‐17β‐glucuronide (E217G) is a cholestatic agent and is considered to be
related to the pathogenesis of intrahepatic cholestasis of pregnancy. In the current study, we …

To explore the role of the abnormal expression of the bile salt export pump (BSEP) and
multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed …

Although the medicinal properties of colchicine (COL) have been widely known for
centuries, its toxicity has been the subject of controversy. The narrow therapeutic window …

The effects of dapsone (DDS) treatment (30mg/kg body wt, twice a day, for 4 days) on biliary
secretory function, with special emphasis on bile salt independent bile flow (BSIF), were …

OBJECTIVE: To investigate the choleretic effect and molecular mechanisms of action of
peppermint oil (PO), the main component of Danshu capsules (Sichuan Jishengtang …

To investigate the effects of geniposidic acid (GPA) on hepato-enteric circulation in
cholestasis rats, and to explore the mechanism based on the sirtuin 1 (Sirt1)-farnesol X …