Abstract Background and Aim Previous studies have shown that rifampicin induced
choleresis, the mechanisms of which have not been described. The aim of this study was to …

The aim is to investigate the influence of the antidiabetic drug gliclazide on the ileal
permeation of the semisynthetic bile acid, MKC, in tissues from healthy and diabetic rats …

Berberine is a bioactive herbal ingredient isolated from the roots and bark of Berberis
aristata or Coptis chinensis. To investigate the detailed pharmacokinetics of berberine and …

Glycyrrhizin (GL) has been used to treat chronic hepatitis in Japan and Europe. It is thought
to induce pseudoaldosteronism via inhibition of type 2 11β-hydroxysteroid dehydrogenase …

The effects of pretreatment with spironolactone, phenobarbital and 3, 4–benzpyrene on
biliary excretion of digoxin was studied in the isolated perfused rat liver system after a single …

Abstract Background/Purpose Rifampicin has been used for the treatment of patients with
jaundice and pruritus. This study evaluated the effect of rifampicin on the expression of …

Purpose. To determine the possible mechanism of poor bioavailability of bicyclol, and clarify
the respective contribution of P-glycoprotein (P-gp) and Cytochrome 3A (CYP3A). Methods …

The present study evaluates the roles of the multidrug resistance-1 P-glycoprotein,
Mdr1a/1b, the bile salt export pump (Bsep), and the multidrug resistance-associated protein …

Biliary elimination of endogenous compounds and xenobiotics usually requires carrier-
mediated systems allowing movement across the canalicular membrane of hepatocytes. The …

Multidrug resistance protein 2 (Mrp2) is considered the major mammalian membrane
transporter of non-bile salt organic anions from liver to bile. Using Mrp2-deficient rats, we …