Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of
undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo …

The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to
play important roles in excretion of various drugs. In the present study, we investigated …

The hepatotoxic effects of geniposide were investigated in rats. Increases in serum alanine
aminotransferase and aspartate aminotransferase activities as a result of oral administration …

Abstract Pinelliae Rhizoma Praeparatum (PRP) as traditional Chinese medicine had been
used for hepatic diseases in combinative forms. However, the effect of PRP was not clear …

Abstract Treatment of rats with nifurtimox, a nitrofuran derivative widely used for the
treatment of Chagas' disease, induced a time-and dose-dependent depletion of liver …

The in vivo relevance of ursodeoxycholate (UDCA) treatment (100 mg/kg/day, per oral tid for
5 days before cholestasis induction followed by the same dosing for 5 days) on hepatic …

Gardenia, as a medicinal and edible herb, has the pharmacological activity of protecting the
liver and cholagogue, but the hepatotoxicity induced by the chemical component genipin …

Phenolsulfonphthalein (PSP) has been selected as a model drug that is eliminated from
both the kidney and liver in rats. Although the renal PSP transport system has been studied …

The main aim of this study was to investigate the effect of various selective cytochrome
P4503A (CYP3A) and/or P-glycoprotein (P-gp) modulators on biliary clearance of …

The effect of oral taurine supplementation on endotoxin-induced cholestasis was
investigated in rat liver. At 12h following lipopolysaccharide (LPS) injection (4mg/kg body …