Topical insulin modulates inflammatory and proliferative phases of burn-wound healing in diabetes-induced rats

FF Azevedo, GV Moreira, CJ Teixeira… - … research for nursing, 2019 - journals.sagepub.com
The healing time of burn wounds depends on surface area and depth of the burn and
associated comorbidities. Diabetes mellitus (DM) causes delays in the healing process by …

Insulin topical modulates inflammatory phase and the angiogenesis of the burns wound healing in diabetic-induced rats

FF Azevedo, CRO Carvalho, MJA Saad… - Diabetology & Metabolic …, 2015 - Springer
Background Burns are wounds caused by exposure to an agent from thermal, electric,
radioactive or chemistry origin which presents attenuated inflammatory response, becoming …

Effect of topical insulin on second-degree burns in diabetic rats

F Azevedo, A Pessoa, G Moreira… - … research for nursing, 2016 - journals.sagepub.com
The healing process is complex in diabetic wounds, and the healing mechanism of burn
wounds is different from that of incisional or excisional wounds. Data from our previous study …

[PDF][PDF] Evaluation of burn wound healing activity of topical regular insulin in non-diabetic and streptozocin-induced diabetic rats

KL Bairy, R Abhinav, SM Satyam - Int J Pharm Sci, 2014 - academia.edu
Objective: The role of insulin in the regulation of energy metabolism, protein synthesis, cell
differentiation and growth suggests that this hormone could also play an essential role in …

Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes

S Apikoglu‐Rabus, FV Izzettin, P Turan… - Clinical and …, 2010 - academic.oup.com
Background. Diabetes is a condition known even in its early stages to impair the normal
course of wound healing, thus leading to chronic wounds. The role of insulin in the …

Effect of insulin on burn wound healing in aging diabetes mellitus rats

J Wu, X Xue, J Liu, X Si, G Yang - Zhongguo xiu fu Chong Jian wai …, 2009 - europepmc.org
Objective To investigate the effect of topical application of insulin on the burn wound healing
in aging diabetes mellitus (DM) rats and to explore its mechanism. Methods Seventy-five …

Influence of insulin therapy on burn wound healing in rats

SV Madibally, V Solomon, RN Mitchell… - Journal of surgical …, 2003 - Elsevier
Background. Insulin is proposed as a therapy for suppressing muscle wasting after burn
trauma although the long-term effects of this therapy on wound healing are not yet known …

Effects of topical insulin on wound healing: a review of animal and human evidences

J Wang, J Xu - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
Wound healing is a complex biological process that repairs damaged tissues and restores
skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a …

Insulin, but not metformin, supports wound healing process in rats with streptozotocin-induced diabetes

M Mieczkowski, B Mrozikiewicz-Rakowska… - Diabetes, Metabolic …, 2021 - Taylor & Francis
Purpose Optimal glycemic control is crucial for proper wound healing in patients with
diabetes. However, it is not clear whether other antidiabetic drugs support wound healing in …

[HTML][HTML] Topical insulin accelerates cutaneous wound healing in insulin-resistant diabetic rats

T Yu, M Gao, P Yang, Q Pei, D Liu, D Wang… - American journal of …, 2017 - ncbi.nlm.nih.gov
Insulin signaling defects could lead to insulin resistance in insulin target organs: typically, in
the muscler, liver, and adipose tissue. We have observed that insulin accelerated diabetic …