Myostatin, or GDF-8 (growth and differentiation factor-8), was first identified through
sequence identity with members of the BMP (bone morphogenetic protein)/TGF-β …

Myostatin is a secreted growth and differentiating factor (GDF‐8) that belongs to the
transforming growth factor‐beta (TGF‐β) superfamily. Targeted disruption of the myostatin …

Myostatin, which was cloned in 1997, is a potent inhibitor of skeletal muscle growth and
member of the tumour growth factor-β family. Disruption of the myostatin gene in mice …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Increasing the size and strength of muscles represents a promising therapeutic strategy for
musculoskeletal disorders, and interest has focused on myostatin, a negative regulator of …

Myostatin, a secreted growth factor, is a member of the TGF‐β superfamily and an inhibitor of
myogenesis. Previously, we have shown that myostatin gene expression is regulated at the …

Myostatin (also known as growth/differentiation factor-8) is a recently identified member of
the transforming growth factor-β family of secreted regulatory factors. Mice having targeted …

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining
both muscle fiber number and size. The myostatin pathway is conserved and regulates …

Myostatin, a TGF-β family member, is a negative regulator of muscle growth. Here, we
generated transgenic mice that expressed myostatin mutated at its cleavage site under the …

Myostatin [MSTN, also known as growth differentiation factor 8 (GDF8)], is an inhibitor of
skeletal muscle growth. Blockade of MSTN function has been reported to result in increased …