Myostatin is a member of the TGF-β superfamily that is essential for proper regulation of
skeletal muscle growth. As do other TGF-β superfamily members, myostatin signals into the …

Myostatin is a transforming growth factor-ß family member that normally acts to limit skeletal
muscle growth. Mice genetically engineered to lack myostatin activity have about twice the …

GDF-8, also known as myostatin, is a member of the transforming growth factor-β (TGF-β)
superfamily of secreted growth and differentiation factors that is expressed in vertebrate …

Since its identification in 1997, myostatin has been considered as a novel and unique
negative regulator of muscle growth, as mstn−/− mice display a dramatic and widespread …

THE PLASTICITY OF SKELETAL muscle continues to fascinate physiologists and cell
biologists. Many of the key molecules in the pathways that signal growth or atrophy of …

Skeletal muscle fibrosis is a major pathological hallmark of chronic myopathies in which
myofibers are replaced by progressive deposition of collagen and other extracellular matrix …

Myostatin, a member of the transforming growth factor-β superfamily, is a secreted growth
factor that is proteolytically processed to give COOH-terminal mature myostatin and NH2 …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

Myostatin, a member of the transforming growth factor-β superfamily, is an attractive target
for muscle disease therapy because of its role as a negative regulator of muscle growth and …

Mutations in myostatin (GDF8) cause marked increases in muscle mass, suggesting that this
transforming growth factor‐β (TGF‐β) superfamily member negatively regulates muscle …