Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

Myostatin belongs to the transforming growth factor beta superfamily and has been shown to
function as an inhibitor of skeletal muscle proliferation and differentiation. To gain insight …

Myostatin (MSTN), a transforming growth factor (TGF)-β superfamily member, has been
shown to negatively regulate muscle growth by inhibiting muscle precursor cell proliferation …

Myostatin mutations in mice and cattle are associated with increased muscularity,
suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the …

Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β
family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by …

Muscle regeneration through myostatin inhibition : Current Opinion in Rheumatology Muscle
regeneration through myostatin inhibition : Current Opinion in Rheumatology Log in or Register …

Inhibition of myostatin signalling or its biological activity has recently emerged as a potential
remedial approach against muscle wasting and degenerative diseases such as muscular …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

Muscle growth results from a set of complex processes including myogenic transcription
factor's expression and activity, cell cycle withdrawal, myoblast fusion in myotubes, and …

Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …