Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

The skeletal muscle of mammals is known to express myostatin (GDF-8) that acts as a potent
negative regulator of skeletal muscle growth. However, the function of GDF-8 is not limited to …

Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking
myostatin show a significant increase in muscle mass and bone density compared to normal …

Myostatin is a secreted TGF-β family member that controls skeletal muscle growth. Humans,
cattle, and dogs carrying natural loss-of-function mutations in the myostatin gene and …

Myostatin deficiency leads to both an increased rate of protein synthesis and skeletal muscle
hypertrophy. However, the mechanisms involved in mediating these effects are not yet fully …

Myostatin, a member of the transforming growth factor (TGF)-β family, plays an important role
in regulating skeletal muscle growth and differentiation. Here we examined the role of …

Myostatin, a member of the transforming growth factor (TGF)-β family of secreted ligands, is
a strong negative regulator of muscle growth. As such, therapeutic inhibitors of myostatin are …

Myostatin (GDF-8) inhibits the activation, proliferation, and differentiation of myogenic
satellite cells. The relative importance of this growth factor is demonstrated in myostatin-null …

Myostatin is a highly conserved protein secreted primarily from skeletal muscle that can
potently suppress muscle growth. This ability to regulate skeletal muscle mass has sparked …

Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human
skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were …