Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …
D Luo, X Dai, H Tian, C Fan, H Xie, N Chen, J Wang… - Phytomedicine, 2023 - Elsevier
Background Novel compounds and more efficient treatment options are urgently needed for
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …
A Novel Flavonoid Kushenol Z from Sophora flavescens Mediates mTOR Pathway by Inhibiting Phosphodiesterase and Akt Activity to Induce Apoptosis in Non-Small …
H Chen, J Yang, J Hao, Y Lv, L Chen, Q Lin, J Yuan… - Molecules, 2019 - mdpi.com
The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine
for the treatment of various lung diseases. In this study, we investigated the mechanism by …
for the treatment of various lung diseases. In this study, we investigated the mechanism by …
Sophoraflavanone G from Sophora flavescens induces apoptosis in triple-negative breast cancer cells
WC Huang, PY Gu, LW Fang, YL Huang, CF Lin… - Phytomedicine, 2019 - Elsevier
Background A compound isolated from Sophora flavescens–sophoraflavanone G (SG)–
showed anti-tumor and anti-inflammatory properties. We previously demonstrated that SG …
showed anti-tumor and anti-inflammatory properties. We previously demonstrated that SG …
[HTML][HTML] Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology …
H Li, J Lin, F Yang, J Deng, J Lai, J Zeng… - Frontiers in …, 2022 - frontiersin.org
Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.
Sanguisorba officinalis L.(SOL), a traditional Chinese herbal medicine called Diyu, has been …
Sanguisorba officinalis L.(SOL), a traditional Chinese herbal medicine called Diyu, has been …
Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway
S Wang, Y Hu, Y Yan, Z Cheng, T Liu - BMC complementary and …, 2018 - Springer
Background Sotetsuflavone is isolated from Cycas revoluta Thunb., which has biological
activity against tumors. However, the anti-proliferative effects of sotetsuflavone on A549 cells …
activity against tumors. However, the anti-proliferative effects of sotetsuflavone on A549 cells …
Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and-induced apoptosis of human lung cancer cells
Y Zhou, Q Tang, S Zhao, F Zhang, L Li, WY Wu… - Tumor Biology, 2014 - Springer
Solamargine (SM), a major steroidal alkaloid glycoside extracted from a traditional Chinese
medicinal herb, Solanum nigrum L.(SNL), has been shown to inhibit growth and induce …
medicinal herb, Solanum nigrum L.(SNL), has been shown to inhibit growth and induce …
Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents
L Wu, G Wang, S Liu, J Wei, S Zhang, M Li, G Zhou… - Scientific reports, 2016 - nature.com
Matrine, an active component of root extracts from Sophora flavescens Ait, is the main
chemical ingredient of Fufang Kushen injection which was approved by Chinese FDA …
chemical ingredient of Fufang Kushen injection which was approved by Chinese FDA …
Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways
L Zhu, S Huang, J Li, J Chen, Y Yao, L Li, H Guo… - Gene, 2020 - Elsevier
Background Sophoridine, a quinolizidine alkaloid extracted from the Chinese herb Sophora
alopecuroides L., has been reported to exert antitumor effects against multiple human …
alopecuroides L., has been reported to exert antitumor effects against multiple human …
Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro
S Wang, X Xu, Y Hu, T Lei, T Liu - Frontiers in Pharmacology, 2019 - frontiersin.org
Non-small cell lung cancer (NSCLC) is a globally scaled disease with a high incidence and
high associated mortality rate. Autophagy is one of the important physiological activities that …
high associated mortality rate. Autophagy is one of the important physiological activities that …
Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL …
X Yi, L Xiang, Y Huang, Y Wang, X He - Phytomedicine, 2018 - Elsevier
Background Our previous study has revealed that the spirostanol saponins isolated from the
rhizomes of Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) …
rhizomes of Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) …