[HTML][HTML] Sotetsuflavone Induces Autophagy in Non-Small Cell Lung Cancer Through Blocking PI3K/Akt/mTOR Signaling Pathway in Vivo and in Vitro

S Wang, X Xu, Y Hu, T Lei, T Liu - Frontiers in Pharmacology, 2019 - frontiersin.org
Non-small cell lung cancer (NSCLC) is a globally scaled disease with a high incidence and
high associated mortality rate. Autophagy is one of the important physiological activities that …

Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL …

X Yi, L Xiang, Y Huang, Y Wang, X He - Phytomedicine, 2018 - Elsevier
Background Our previous study has revealed that the spirostanol saponins isolated from the
rhizomes of Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) …

[HTML][HTML] Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer

Z Peng, Q Guan, J Luo, W Deng, J Liu, R Yan, W Wang - BMC cancer, 2020 - Springer
Background As a natural alkaloid product isolated from Sophora alopecuroides. L,
Sophoridine reshapes gastric cancer immune microenvironment via inhibiting chemotaxis …

Sophoraflavanone G induces apoptosis in human leukemia cells and blocks MAPK activation

ZY Li, WC Huang, RS Tu, PY Gu, CF Lin… - The American Journal …, 2016 - World Scientific
Sophoraflavanone G (SG) was isolated from Sophora flavescens. Previously, we have found
that SG is able to suppress the inflammatory response in lipopolysaccharide-stimulated …

[HTML][HTML] Matrine induces mitochondrial apoptosis in cisplatin‑resistant non-small cell lung cancer cells via suppression of β-catenin/survivin signaling

HQ Wang, JJ Jin, J Wang - Oncology Reports, 2015 - spandidos-publications.com
Matrine is an alkaloid isolated from Sophora flavescens and shows anticancer activities. The
present study was carried out to determine the cytotoxic effects of matrine on cisplatin …

[HTML][HTML] Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells

C Tan, X Qian, R Jia, M Wu… - Oncology Reports, 2013 - spandidos-publications.com
Non-small cell lung carcinoma (NSCLC) is one of the most refractory cancers in the clinic; it
is insensitive to chemotherapy and is usually excised. However, screening natural …

Total steroidal saponins from black nightshade (Solanum nigrum L.) overcome tumor multidrug resistance by inducing autophagy‐mediated cell death in vivo and in …

Y Wang, S Wang, J Xu, Y Wang, L Xiang… - Phytotherapy …, 2023 - Wiley Online Library
Multiple drug resistance (MDR) often occurs after prolonged chemotherapy, leading to
refractory tumors and cancer recurrence. In this study, we demonstrated that the total …

Caspase and mitogen activated protein kinase pathways are involved in Solanum lyratum herba induced apoptosis

JH Lee, YH Lee, HJ Lee, HJ Lee, EO Lee… - Journal of …, 2009 - Elsevier
AIM OF STUDY: Solanum lyratum herba (SLH) has been traditionally used for the treatment
of febrifuge, diarrhea, eye disease and cancer with little scientific evidences. Thus, in the …

Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen …

S Kajimoto, N Takanashi, T Kajimoto… - … journal of cancer, 2002 - Wiley Online Library
Screening of various natural products in a search for novel inducers of apoptosis in human
leukemia cells led us to identify the strong apoptosis-inducing activity in a fraction extracted …

[HTML][HTML] Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer

JF Teng, QB Mei, XG Zhou, Y Tang, R Xiong, WQ Qiu… - Cancers, 2020 - mdpi.com
Trillium tschonoskii Maxim (TTM), a traditional Chinese medicine, has been demonstrated to
have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from …