Introduction: Inflammatory reactions, including those mediated by the NLRP3
inflammasome, maintain the body's homeostasis by removing pathogens, repairing …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

The NLRP3 inflammasome represents a cytoplasmic multiprotein complex with the
capability to recognize a wide range of pathogen-derived, environmental, and endogenous …

Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of
preclinical models. As excitement in this field has grown, several companies have recently …

Highlights•Targeting the NLRP3 inflammasome has shown therapeutic effects in
inflammatory diseases.•The use of specific NLRP3 inhibitors reduces off-target …

The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …

NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …

The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome has been
linked to the release of pro-inflammatory cytokines and is essential for innate defence …