Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …

Background Genome-wide association studies have identified numerous genetic regions
that influence cross-sectional lung function. Longitudinal decline in lung function also …

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic
obstructive pulmonary disease (COPD), predictive performance is limited when the …

Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease
(COPD) and its interactions with genetic variants could affect lung function. However, few …

Background: Smoking is the strongest environmental risk factor for reduced pulmonary
function. The genetic component of various pulmonary traits has also been demonstrated …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Background Pulmonary function measures obtained by spirometry are used to diagnose
chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted …

Background Genetic factors and smoking contribute to chronic obstructive pulmonary
disease (COPD), but whether a combined polygenic risk score (PRS) is associated with …

Background Impaired lung function is predictive of mortality and is a key component of
chronic obstructive pulmonary disease. Lung function has a strong genetic component but is …

Background Pulmonary function decline is a major contributor to morbidity and mortality
among smokers. Post bronchodilator FEV 1 and FEV 1/FVC ratio are considered the …