Aquaporins: phylogeny, structure, and physiology of water channels

JB Heymann, A Engel - Physiology, 1999 - journals.physiology.org
How water permeates cellular membranes and what this means for cell functioning and
several diseases are now emerging from the study of the aquaporins (AQPs), the water …

Aquaporin water channels–from atomic structure to clinical medicine

P Agre, LS King, M Yasui, WB Guggino… - The Journal of …, 2002 - Wiley Online Library
The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

Structure and function of aquaporin water channels

AS Verkman, AK Mitra - American Journal of Physiology …, 2000 - journals.physiology.org
The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size∼
30 kDa) that are expressed at plasma membranes in many cells types involved in fluid …

[HTML][HTML] Aquaporin water channels: molecular mechanisms for human diseases

P Agre, D Kozono - FEBS letters, 2003 - Elsevier
Although water is the major component of all biological fluids, the molecular pathways for
water transport across cell membranes eluded identification until the discovery of the …

From structure to disease: the evolving tale of aquaporin biology

LS King, D Kozono, P Agre - Nature reviews Molecular cell biology, 2004 - nature.com
Our understanding of the movement of water through cell membranes has been greatly
advanced by the discovery of a family of water-specific, membrane-channel proteins—the …

Molecular biology of aquaporins

C Li, W Wang - Aquaporins, 2017 - Springer
Aquaporins (AQPs) are a family of membrane water channels that basically function as
regulators of intracellular and intercellular water flow. To date, thirteen AQPs, which are …

Cellular and molecular biology of the aquaporin water channels

M Borgnia, S Nielsen, A Engel… - Annual review of …, 1999 - annualreviews.org
▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Discovery of the aquaporins and development of the field

JM Carbrey, P Agre - Aquaporins, 2009 - Springer
The study of water transport began long before the molecular identification of water
channels with studies of water-permeable tissues. The discovery of the first aquaporin …

Aquaporins: water channel proteins of the cell membrane

K Takata, T Matsuzaki, Y Tajika - Progress in histochemistry and …, 2004 - Elsevier
Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

P Kitchen, RE Day, MM Salman, MT Conner… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …