The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Background Parkinson's disease (PD) causes a loss of neuromelanin‐positive,
noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor …

The locus coeruleus (LC) is a region in the brainstem that produces noradrenaline and is
involved in both normal and pathological brain function. Pupillometry, the measurement of …

Nowadays it is well accepted that in Parkinson's disease (PD), the neurodegenerative
process occurs in stages and that damage to other areas precedes the neuronal loss in the …

The noradrenergic theory of Cognitive Reserve (Robertson, 2013–2014) postulates that the
upregulation of the locus coeruleus—noradrenergic system (LC–NA) originating in the …

In Parkinson's disease (PD), there is a significant loss of noradrenergic neurons in the locus
coeruleus (LC) in addition to the loss of dopaminergic neurons in the substantia nigra (SN) …

There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC)
is important for later-life cognition. Less understood is how LC integrity relates to brain …

The locus ceruleus (LC) contains norepinephrine (NE)-synthesizing neurons that send
diffuse projections throughout the CNS. The LC-NE system has a major role in arousal …

Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related
neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this …

Catecholamine neurons of the locus coeruleus (LC) in the dorsal pontine tegmentum
innervate the entire neuroaxis, with signaling actions implicated in the regulation of …