The placentas of women who suffer an episode of psychosis during pregnancy have increased lipid peroxidation with evidence of ferroptosis

MA Ortega, O Fraile-Martinez, C García-Montero… - Biomolecules, 2023 - mdpi.com
Psychosis is a complex entity characterized by psychological, behavioral, and motor
alterations resulting in a loss of contact with reality. Although it is not common, pregnancy …

Evidence of increased oxidative stress in the placental tissue of women who suffered an episode of psychosis during pregnancy

MA Ortega, O Fraile-Martinez, C García-Montero… - Antioxidants, 2023 - mdpi.com
Psychosis is a complex clinical syndrome resulting in a loss of contact with reality and
alterations in behavior and sensorial and motor functions. Although the onset of psychosis …

Oxidative Stress, Lipid Peroxidation and Ferroptosis Are Major Pathophysiological Signatures in the Placental Tissue of Women with Late-Onset Preeclampsia

MA Ortega, LM Garcia-Puente, O Fraile-Martinez… - Antioxidants, 2024 - mdpi.com
Preeclampsia, a serious and potentially life-threatening medical complication occurring
during pregnancy, is characterized by hypertension and often accompanied by proteinuria …

Assessment of tissue expression of the oxytocin–vasopressin pathway in the placenta of women with a first-episode psychosis during pregnancy

MA Ortega, C García-Montero… - International Journal of …, 2023 - mdpi.com
Psychosis refers to a mental health condition characterized by a loss of touch with reality,
comprising delusions, hallucinations, disorganized thought, disorganized behavior …

The ferroptosis-NLRP1 inflammasome: the vicious cycle of an adverse pregnancy

L Meihe, G Shan, K Minchao, W Xiaoling… - Frontiers in cell and …, 2021 - frontiersin.org
One of the hallmarks of placental dysfunction is the increase of oxidative stress. This
process, along with the overexpression of the inflammasome, creates a downward spiral that …

Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative …

SRA El-Khalik, RR Ibrahim, MTA Ghafar… - Journal of Assisted …, 2022 - Springer
Purpose Ferroptosis is associated with oxidative stress (OS) and is caused by iron-
dependent lipid-peroxidative damage, but its role in PE is unclear. The aim of this study is to …

Ferroptosis, trophoblast lipotoxic damage, and adverse pregnancy outcome

O Beharier, K Kajiwara, Y Sadovsky - Placenta, 2021 - Elsevier
Programmed cell death is a central process in the control of tissue development, organismal
physiology, and disease. Ferroptosis is a recently identified form of programmed cell death …

[HTML][HTML] miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia

H Zhang, Y He, J Wang, M Chen, J Xu, M Jiang, Y Feng… - Redox biology, 2020 - Elsevier
Oxidative stress is a major cause of adverse outcomes in preeclampsia (PE). Ferroptosis, ie
programmed cell death from iron-dependent lipid peroxidation, likely mediates PE …

Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood.

MA Camkurt, E Fındıklı, M Bakacak… - Journal of psychiatric …, 2016 - Elsevier
The investigation of fetal cord blood (FCB) during child delivery has created a novel topic in
the field of psychiatric research. The umbilical vein receives nutrients and oxygen from the …

[HTML][HTML] Iron metabolism and ferroptosis: A pathway for understanding preeclampsia

KE Gumilar, B Priangga, CH Lu, EG Dachlan… - Biomedicine & …, 2023 - Elsevier
Preeclampsia (PE) is a serious medical condition that poses a significant health risk to
women and children worldwide, particularly in the middle-and low-income countries. It is a …