Secondary progressive in contrast to relapsing‐remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T‐cell function and FOXP3 expression

K Venken, N Hellings, K Hensen… - Journal of …, 2006 - Wiley Online Library
Accumulating evidence indicates an immunosuppressive role for CD4+ CD25+ regulatory T
cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with …

Compromised CD4+ CD25high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3 …

K Venken, N Hellings, M Thewissen, V Somers… - …, 2008 - Wiley Online Library
Summary CD4+ CD25high regulatory T cells (Tregs) of patients with relapsing‐remitting
(RR) multiple sclerosis (MS), in contrast to those of patients with secondary progressive (SP) …

CD4+ CD25+ FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis

M Kumar, N Putzki, V Limmroth, R Remus… - Journal of …, 2006 - Elsevier
Multiple sclerosis (MS) is an autoimmune disorder directed against self antigens of the
central nervous system. CD4+ CD25+ FoxP3+ regulatory T cell (Treg) mediated suppression …

Regulatory T cells fail to suppress CD4+ T‐bet+ T cells in relapsing multiple sclerosis patients

G Frisullo, V Nociti, R Iorio, AK Patanella… - …, 2009 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system and a defect in the regulatory T‐cell subset seems to be involved in the …

CD8+ Foxp3+ T cells in peripheral blood of relapsing-remitting multiple sclerosis patients

G Frisullo, V Nociti, R Iorio, D Plantone, AK Patanella… - Human immunology, 2010 - Elsevier
A defect of CD4+ regulatory T cells (Treg) seems to be involved in the pathogenesis of
multiple sclerosis (MS). Besides Treg, CD8+ T cells also can suppress the immune …

Glucocorticoids increase CD4+CD25high cell percentage and Foxp3 expression in patients with multiple sclerosis

M Braitch, S Harikrishnan, RA Robins… - Acta Neurologica …, 2009 - Wiley Online Library
Objectives–To determine whether percentages of CD4+ CD25high T cells (a group of
regulatory T cells, Treg) differ in patients with multiple sclerosis (MS) in relapse vs remission …

T regulatory cells are markers of disease activity in multiple sclerosis patients

D Dalla Libera, D Di Mitri, A Bergami, D Centonze… - PloS one, 2011 - journals.plos.org
FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the
determination of clinical recurrences. Contradictory reports are, however, available …

Intracerebral Human Regulatory T Cells: Analysis of CD4+CD25+FOXP3+ T Cells in Brain Lesions and Cerebrospinal Fluid of Multiple Sclerosis Patients

B Fritzsching, J Haas, F König, P Kunz, E Fritzsching… - PloS one, 2011 - journals.plos.org
Impaired suppressive capacity of CD4+ CD25+ FOXP3+ regulatory T cells (Treg) from
peripheral blood of patients with multiple sclerosis (MS) has been reported by multiple …

Disturbed regulatory T cell homeostasis in multiple sclerosis

K Venken, N Hellings, R Liblau, P Stinissen - Trends in molecular medicine, 2010 - cell.com
The pathological features of multiple sclerosis (MS), a chronic inflammatory disorder of the
central nervous system, support an autoimmune etiology. Strong evidence has been …

T regulatory cells lacking CD25 are increased in MS during relapse

M Fransson, J Burman, C Lindqvist, C Atterby… - …, 2010 - Taylor & Francis
Dysregulation of inflammatory responses is considered to be a key element in autoreactive
immune responses. T regulatory cells (Tregs) are important to maintain self-tolerance and …