Osteocalcin (OC), which is a marker of the mature osteoblasts, can also be found in
posthypertrophic chondrocytes of the epiphyseal growth plate, but not in chondrocytes of the …

Alterations in osteoblast metabolism are involved in the pathogenesis of typical subchondral
bone changes in osteoarthritis (OA). Osteocalcin is a specific bone protein, synthesised by …

Few studies have investigated the factors or mechanisms that may lead to structural
changes in OA bone. This study examines the in vivo expression of messenger RNA …

Genetic studies and molecular cloning approaches have been successfully used to identify
several transcription factors that regulate the numerous stages of cartilage development …

Articular chondrocytes maintain cartilage matrix turnover and have the capacity for anabolic
and catabolic activities that can be influenced by injury and disease. This study tested the …

There is now general agreement that osteoarthritis (OA) involves all structures in the affected
joint, culminating in the degradation of the articular cartilage. It is appropriate to focus …

Osteoarthritis (OA) is a degenerative cartilage disease with varying degrees of severity
within a given joint. The purpose of this study was to define a sampling procedure for …

Osteocalcin (OC) is known to be a bone tissue-specific protein, expression of which is
believed to be controlled by the OC promoter. In this communication, we provided evidence …

Objectives: To investigate changes in gene expression in fibrillated and intact human
osteoarthritis (OA) cartilage for evidence of an altered chondrocyte phenotype and …

Objective To determine the phenotype of osteoblasts from the sclerotic zones of human
osteoarthritic (OA) subchondral bone. Methods Human osteoblasts were isolated from …