Chlamydial hsp60 and the immunopathogenesis of chlamydial disease.

RP Morrison - Seminars in immunology, 1991 - europepmc.org
Chlamydia trachomatis is a major cause of ocular and genital tract infections of humans.
These infections generally resolve without adverse sequelae, but occasionally severe …

Monoclonal antibodies define genus-specific, species-specific, and cross-reactive epitopes of the chlamydial 60-kilodalton heat shock protein (hsp60): specific …

Y Yuan, K Lyng, YX Zhang, DD Rockey… - Infection and …, 1992 - Am Soc Microbiol
Ocular and urogenital tract infections with Chlamydia trachomatis can progress to chronic
inflammatory diseases that produce blindness and tubal infertility. The pathophysiology of …

Heat shock protein 60 specific T‐cell response in chlamydial infections

A Kinnunen, J Paavonen… - Scandinavian Journal of …, 2001 - Wiley Online Library
Heat shock proteins (HSPs) of most pathogens, including Chlamydia, are major immune
targets of both humoral‐and cell‐mediated immune mechanisms. During the last decade …

Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10

Y Yi, X Yang, RC Brunham - Infection and immunity, 1997 - Am Soc Microbiol
The immunopathologic sequelae of chlamydial infection are correlated with immune
responses to the Chlamydia trachomatis heat shock protein 60 (hsp60). One pathogenic …

Antibody responses to the chlamydial heat shock proteins hsp60 and hsp70 are H-2 linked

G Zhong, RC Brunham - Infection and immunity, 1992 - Am Soc Microbiol
The effects of both H-2 and non-H-2 genes on antibody responses to two Chlamydia
trachomatis heat shock proteins (hsp60 and hsp70) were investigated. These chlamydial …

Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein

MC Cerrone, JJ Ma, RS Stephens - Infection and immunity, 1991 - Am Soc Microbiol
We isolated and sequenced the gene for the chlamydial heat shock protein 60 (HSP-60)
from a Chlamydia trachomatis genomic library by molecular genetic methods. The DNA …

[HTML][HTML] Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract

IM Linhares, SS Witkin - Cell Stress and Chaperones, 2010 - Elsevier
Chlamydia trachomatis is an obligate intracellular bacterium that infects chiefly urogenital
and ocular epithelial cells. In some infected women the microorganism migrates to the upper …

Chlamydial heat shock proteins and trachoma

HR Taylor, IW Maclean, RC Brunham, S Pal… - Infection and …, 1990 - Am Soc Microbiol
Two chlamydial proteins (HSP-60 and HSP-70) have marked homology with bacterial and
mammalian heat shock proteins. Previous studies have indicated that when inoculated into …

Mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis

T Agrawal, V Vats, S Salhan… - Clinical & Experimental …, 2007 - academic.oup.com
Most of the studies on 60-kDa and 10-kDa chlamydial heat shock proteins (HSPs) to date
have been carried out with blood lymphocytes or serum antibody responses, which do not …

Chlamydial heat shock proteins and disease pathology: new paradigms for old problems?

D LaVerda, MV Kalayoglu… - Infectious Diseases in …, 1999 - Wiley Online Library
The mucosal pathogen Chlamydia trachomatis affects hundreds of millions of people
worldwide and is a significant cause of sexually transmitted disease. Although most acute …