A series of N-alkyl or aryl substituted isoindigo derivatives have been synthesized and their
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …

The bis-indole indigoids are a promising protein kinase inhibitor scaffold to be further
evaluated against the numerous human diseases that imply abnormal regulation of kinases …

In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …

A new series of benzimidazole‐oxindole hybrids 8a–x was discovered as dual cyclin‐
dependent kinase (CDK2) and glycogen synthase kinase‐3‐beta (GSK‐3β) inhibitors with …

In the course of studies on the preparation of potential kinase inhibitors, we were interested
in the synthesis of diversely substituted glycosyl-isoindigo derivatives. To get an insight into …

Abstract Indirubin-3′-monoxime (IM) is a potent cyclin-dependent kinase (CDK) inhibitor.
Twenty novel IM derivatives were prepared to investigate the structure–activity relationships …

In the course of structure–activity relationship studies we were interested in the synthesis of
isoindigo and 7′-azaisoindigo derivatives substituted at the N-1 position by a 1-(2, 3, 4, 6 …

A series of novel 7‐azaisoindigo derivatives 3–14 were designed, synthesized, and
structurally characterized by IR, 1H‐NMR, 13C‐NMR, mass spectra, and elemental …

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …

The discovery and development of CDK2 inhibitors has currently been validated as a hot
topic in cancer therapy. Herein, a series of novel N-(pyridin-3-yl) pyrimidin-4-amine …