Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase …
P Zhao, Y Li, G Gao, S Wang, Y Yan, X Zhan… - European Journal of …, 2014 - Elsevier
A series of N-alkyl or aryl substituted isoindigo derivatives have been synthesized and their
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …
Synthesis and kinase inhibitory activity of novel substituted indigoids
A Beauchard, H Laborie, H Rouillard, O Lozach… - Bioorganic & medicinal …, 2009 - Elsevier
The bis-indole indigoids are a promising protein kinase inhibitor scaffold to be further
evaluated against the numerous human diseases that imply abnormal regulation of kinases …
evaluated against the numerous human diseases that imply abnormal regulation of kinases …
Design, synthesis, antineoplastic activity of new pyrazolo [3, 4-d] pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME …
In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
Benzimidazole‐oxindole hybrids: A novel class of selective dual CDK2 and GSK‐3β inhibitors of potent anticancer activity
HT Abdel‐Mohsen, YM Syam… - Archiv der …, 2024 - Wiley Online Library
A new series of benzimidazole‐oxindole hybrids 8a–x was discovered as dual cyclin‐
dependent kinase (CDK2) and glycogen synthase kinase‐3‐beta (GSK‐3β) inhibitors with …
dependent kinase (CDK2) and glycogen synthase kinase‐3‐beta (GSK‐3β) inhibitors with …
In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives
M Sassatelli, F Bouchikhi, B Aboab, F Anizon… - Anti-Cancer …, 2007 - journals.lww.com
In the course of studies on the preparation of potential kinase inhibitors, we were interested
in the synthesis of diversely substituted glycosyl-isoindigo derivatives. To get an insight into …
in the synthesis of diversely substituted glycosyl-isoindigo derivatives. To get an insight into …
Discovery of novel indirubin-3′-monoxime derivatives as potent inhibitors against CDK2 and CDK9
L Yan, F Lai, X Chen, Z Xiao - Bioorganic & Medicinal Chemistry Letters, 2015 - Elsevier
Abstract Indirubin-3′-monoxime (IM) is a potent cyclin-dependent kinase (CDK) inhibitor.
Twenty novel IM derivatives were prepared to investigate the structure–activity relationships …
Twenty novel IM derivatives were prepared to investigate the structure–activity relationships …
Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7′-azaisoindigo derivatives substituted by Sonogashira cross-coupling
F Bouchikhi, F Anizon, P Moreau - European journal of medicinal chemistry, 2009 - Elsevier
In the course of structure–activity relationship studies we were interested in the synthesis of
isoindigo and 7′-azaisoindigo derivatives substituted at the N-1 position by a 1-(2, 3, 4, 6 …
isoindigo and 7′-azaisoindigo derivatives substituted at the N-1 position by a 1-(2, 3, 4, 6 …
Synthesis and Biological Evaluation of 7‐Azaisoindigo Derivatives
ZH Wang, T Wang, SN Yao, J Chen… - … der Pharmazie: An …, 2010 - Wiley Online Library
A series of novel 7‐azaisoindigo derivatives 3–14 were designed, synthesized, and
structurally characterized by IR, 1H‐NMR, 13C‐NMR, mass spectra, and elemental …
structurally characterized by IR, 1H‐NMR, 13C‐NMR, mass spectra, and elemental …
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
Design, synthesis, and biological evaluation of N-(pyridin-3-yl) pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy
WB Zeng, TY Ji, YT Zhang, YF Ma, R Li, WW You… - Bioorganic …, 2024 - Elsevier
The discovery and development of CDK2 inhibitors has currently been validated as a hot
topic in cancer therapy. Herein, a series of novel N-(pyridin-3-yl) pyrimidin-4-amine …
topic in cancer therapy. Herein, a series of novel N-(pyridin-3-yl) pyrimidin-4-amine …
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