Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood–brain water uptake and confers barrier function on perivascular astrocyte endfeet

NN Haj-Yasein, GF Vindedal… - Proceedings of the …, 2011 - National Acad Sciences
Tissue-and cell-specific deletion of the Aqp4 gene is required to differentiate between the
numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout …

Inhibition of AQP4 expression in astrocytes by RNAi determines alterations in cell morphology, growth, and water transport and induces changes in ischemia related …

GP Nicchia, A Frigeri, GM Liuzzi, M Svelto - The FASEB journal, 2003 - Wiley Online Library
Recent studies indicate a key role of aquaporin (AQP) 4 in astrocyte swelling and brain
edema and suggest that AQP4 inhibition may be a new therapeutic way for reducing …

Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: a combined MRI–histological study

T Tourdias, I Dragonu, Y Fushimi, MSA Deloire… - Neuroimage, 2009 - Elsevier
Hydrocephalus features include ventricular dilatation and periventricular edema due to
transependymal resorption of cerebrospinal fluid (CSF). Aquaporin 4 (AQP4), a water …

Aquaporin-4 water channels and synaptic plasticity in the hippocampus

HE Scharfman, DK Binder - Neurochemistry international, 2013 - Elsevier
Abstract Aquaporin-4 (AQP4) is the major water channel expressed in the central nervous
system (CNS) and is primarily expressed in glial cells. Many studies have shown that AQP4 …