Many pharmaceutical drugs in the marketplace and discovery pipeline suffer from poor
aqueous solubility, thereby limiting their effectiveness for oral delivery. The use of an …

Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …

Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …

Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …

Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …

Drug loading is an important parameter known to impact the release rate of a poorly soluble
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …