An update on bronchodilators in Phase I and II clinical trials

M Cazzola, P Rogliani, A Segreti… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: Inhaled bronchodilators are the mainstay of the current management of COPD
at all stages of the disease, and are critical in the symptomatic management of asthma …

Emerging inhaled bronchodilators: an update

M Cazzola, MG Matera - European Respiratory Journal, 2009 - Eur Respiratory Soc
Bronchodilators remain central to the symptomatic management of chronic obstructive
pulmonary disease and asthma, and, for this reason and also because the patent protection …

Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera - Pharmacological Reviews, 2012 - ASPET
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Long-acting bronchodilators in COPD: where are we now and where are we going?

M Cazzola, C Page - Breathe, 2014 - Eur Respiratory Soc
Educational aims To discuss fundamental questions relating to the use of bronchodilators
that can lead to an optimisation of their utilisation. To describe new bronchodilators that …

Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends

P Montuschi, G Ciabattoni - Journal of medicinal chemistry, 2015 - ACS Publications
Inhaled bronchodilators, including long-acting muscarinic receptor antagonists (LAMA) and
long-acting β2-adrenoreceptor agonists (LABA), are the mainstay of pharmacological …

Novel bronchodilators for the treatment of chronic obstructive pulmonary disease

MG Matera, CP Page, M Cazzola - Trends in pharmacological sciences, 2011 - cell.com
Because of the central role of bronchodilators in the treatment of respiratory diseases, there
is still considerable interest in finding novel classes of broncholytic drugs. It can be …

New dual-acting bronchodilator treatments for COPD, muscarinic antagonists and β2 agonists in combination or combined into a single molecule

P Norman - Expert Opinion on Investigational Drugs, 2013 - Taylor & Francis
Introduction: It has long been known that combining short-acting muscarinic antagonists and
β2 agonists produces additive effects on the lung function of patients with chronic obstructive …

Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease

J Nichols - … : The Journal of Human Pharmacology and Drug …, 2007 - Wiley Online Library
The Global Obstructive Lung Disease (GOLD) guidelines suggest the potential use of
combination bronchodilator therapy in patients with stage II or higher chronic obstructive …

Emerging trends in the therapy of COPD: bronchodilators as mono-and combination therapies

MF Fitzgerald, JC Fox - Drug discovery today, 2007 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that is
characterized by progressive airway obstruction that, unlike asthma, is relatively insensitive …

Bronchodilator combination therapy for the treatment of chronic obstructive pulmonary disease

S Sethi, C Cote - Current Clinical Pharmacology, 2011 - ingentaconnect.com
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality,
and its prevalence is rising worldwide. Bronchodilators remain the cornerstone of COPD …