[HTML][HTML] Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates
PA Lawlor, RJ Bland, A Mouravlev, D Young… - Molecular therapy, 2009 - cell.com
Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic
gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery …
gene transfer into the central nervous system (CNS). To date, AAV-mediated gene delivery …
[HTML][HTML] Comparative transduction efficiency of AAV vector serotypes 1–6 in the substantia nigra and striatum of the primate brain
EA Markakis, KP Vives, J Bober, S Leichtle, C Leranth… - Molecular Therapy, 2010 - cell.com
Vectors derived from adeno-associated virus (AAV) are promising candidates for neural cell
transduction in vivo because they are nonpathogenic and achieve long-term transduction in …
transduction in vivo because they are nonpathogenic and achieve long-term transduction in …
[HTML][HTML] Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain
CN Cearley, LH Vandenberghe, MK Parente… - Molecular therapy, 2008 - cell.com
A wide diversity of adeno-associated virus (AAV) structural proteins uncovered from latent
genomes in primate tissue has expanded the number of AAV vector serotypes, which can …
genomes in primate tissue has expanded the number of AAV vector serotypes, which can …
Transduction of the central nervous system after intracerebroventricular injection of adeno-associated viral vectors in neonatal and juvenile mice
S Gholizadeh, S Tharmalingam… - Human gene therapy …, 2013 - liebertpub.com
Several neurodevelopmental and neurodegenerative disorders affecting the central nervous
system are potentially treatable via viral vector-mediated gene transfer. Adeno-associated …
system are potentially treatable via viral vector-mediated gene transfer. Adeno-associated …
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or-2 serotypes for widespread gene delivery to the neonatal mouse brain
MLD Broekman, LA Comer, BT Hyman… - Neuroscience, 2006 - Elsevier
Adeno-associated virus (AAV) vectors have gained a preeminent position in the field of gene
delivery to the normal brain through their ability to achieve extensive transduction of neurons …
delivery to the normal brain through their ability to achieve extensive transduction of neurons …
[HTML][HTML] Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to …
C Burger, OS Gorbatyuk, MJ Velardo, CS Peden… - Molecular Therapy, 2004 - cell.com
Recombinant adeno-associated virus 2 (rAAV2) has been shown to deliver genes to
neurons effectively in the brain, retina, and spinal cord. The characterization of new AAV …
neurons effectively in the brain, retina, and spinal cord. The characterization of new AAV …
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain
JM Taymans, LH Vandenberghe, CVD Haute… - Human gene …, 2007 - liebertpub.com
Recombinant adeno-associated virus serotype 2 (rAAV2) vectors have been shown to
deliver genes effectively to neurons in the brain, retina, and spinal cord. The characterization …
deliver genes effectively to neurons in the brain, retina, and spinal cord. The characterization …
[HTML][HTML] Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain
GP Swain, M Prociuk, JH Bagel, P O'donnell, K Berger… - Gene therapy, 2014 - nature.com
Canine models have many advantages for evaluating therapy of human central nervous
system (CNS) diseases. In contrast to nonhuman primate models, naturally occurring canine …
system (CNS) diseases. In contrast to nonhuman primate models, naturally occurring canine …
[HTML][HTML] Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain
Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy
and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression …
and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression …
Selective and rapid uptake of adeno-associated virus type 2 in brain
JS Bartlett, RJ Samulski, TJ Mccown - Human gene therapy, 1998 - liebertpub.com
Recombinant adeno-associated virus (AAV) vectors effectively transfer and express foreign
genes in the brain. The transferred genes, however, are selectively expressed in neurons …
genes in the brain. The transferred genes, however, are selectively expressed in neurons …
相关搜索
- selective transduction glial cells
- nonhuman primates aav serotypes
- nonhuman primates mammalian brain
- nonhuman primates gene delivery
- mice brain aav transduction
- aav vector substantia nigra
- substantia nigra primate brain
- aav vector transduction efficiency
- aav vector primate brain
- substantia nigra transduction efficiency
- primate brain transduction efficiency
- vector serotypes mouse brain
- timing of injection aav transduction
- mice brain capsid serotype
- nonhuman primates glial cells
- aav serotypes glial cells