Skin aging is one of the most evident signs of human aging. Modification of the skin during
the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity …

Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

Skin ageing is a complex process that is determined by both intrinsic and extrinsic factors,
which leads to a progressive loss of structure and function. There is extensive evidence …

Skin aging appears to be the result of two overlapping processes, intrinsic and extrinsic. It is
well accepted that oxidative stress contributes significantly to extrinsic skin aging, although …

Aging is a universal process that can cause diminished function of organs and various
diseases. The most striking consequences of aging can be seen visibly on the skin, which …

Skin is a highly metabolic tissue which possesses the largest surface area in the body and
serves as the protective layer for internal organs [1]. Skin is also a major candidate and …

Aging is a major cause of many degenerative diseases. The most intuitive consequence of
aging is mainly manifested on the skin, resulting in cumulative changes in skin structure …

Here we aim to describe each factor that leads to skin aging and describe their mechanisms.
A PubMed database searches (from January 2004 to March 2014) using aging and skin as …

Aging of the skin has fascinated researchers for decades not only to ultimately prevent
wrinkle formation, but also because the skin represents an excellent and accessible model …

Human skin is constantly directly exposed to the air, solar radiation, environmental
pollutants, or other mechanical and chemical insults, which are capable of inducing the …