Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in
Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive …

Toll-like receptor 4 (TLR4) signaling triggers autophagy, which has been linked to both
adaptive and innate immunity. Engagement of TLR4 recruits to the receptor complex Beclin …

Autophagy is a degradation of the cytoplasm and it induces autophagic cell death in several
neurodegenerative conditions. Beclin 1, a Bcl-2-interacting protein, is known to be a …

Microglia-mediated inflammation plays an important role in the pathogenesis of several
neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has …

Microglial activation-induced neuroinflammation is closely associated with the development
of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological …

Inflammation and autophagy are two critical cellular processes. The relationship between
these two processes is complex and includes the suppression of inflammation by …

Autophagy defects are implicated in multiple late-onset neurodegenerative diseases
including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's, Huntington's, and …

Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …

Autophagy and apoptosis are crucial cellular housekeeping and tissue survival
mechanisms. There is emerging evidence of important crosstalk between apoptosis and …

Autophagy-lysosome pathway (ALP) disruption is considered pathogenic in multiple
neurodegenerative diseases; however, current methods are inadequate to investigate …