Abstract Background Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are
suspected to play a role in the neuroinflammation observed in Alzheimer's disease (AD); no …

The Beclin-1 protein is essential for the initiation of autophagy, and recent studies suggest
this function may be compromised in Alzheimer's disease (AD). In addition, in vitro studies …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
presence of intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau …

Growing evidence supports an active role for dysregulated macroautophagy (autophagic
stress) in neuronal cell death and neurodegeneration. Alterations in mitochondrial function …

Microglia have multiple functions in regulating homeostasis in the central nervous system
(CNS), and microglial inflammation is thought to play a role in the etiology of the …

There is extensive evidence that accumulation of mononuclear phagocytes including
microglial cells, monocytes, and macrophages at sites of β-amyloid (Aβ) deposition in the …

Microglia are important immune cells in the central nervous system (CNS) that undergo
turnover throughout the lifespan. If microglial debris is not removed in a timely manner …

Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and
neurodegenerative diseases, but the molecular mechanism remains elusive. Previous …

Although autophagy maintains normal neural function by degrading misfolded proteins, little
is known about how neurons activate this integral response. Furthermore, classical methods …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …