Neuroinflammation and autophagy dysfunction are closely related to the development of
neurodegeneration such as Parkinson's disease (PD). However, the role of autophagy in …

During autophagy, a double membrane envelops cellular material for trafficking to the
lysosome. Human beclin-1 and its yeast homologue, Atg6/Vps30, are scaffold proteins …

Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth
and development, and represents the major pathway by which the cell maintains a balance …

Neuroinflammation is considered one of major factors in the pathogenesis of Alzheimer's
disease (AD). In particular, inflammasome activation, including NLRP3 inflammasome in …

Background The proinflammatory cytokine interleukin-1β (IL-1β) is overexpressed in
Alzheimer disease (AD) as a key regulator of neuroinflammation. Amyloid-β (Aβ) peptide …

Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis,
development, immunity, tumor suppression, metabolism, prevention of neurodegeneration …

Oxidative stress-mediated activation of NLRP3 inflammasome in microglia is critical in the
development of neurodegerative diseases such as Alzheimer's disease (AD), Parkinson …

Autophagy, a bulk degradation of subcellular constituents, is activated in several
neurodegenerative conditions. Beclin 1, a Bcl2 interacting protein, was found to promote …

Abstract The Vacuole Membrane Protein 1-VMP1-is a pancreatitis-associated
transmembrane protein whose expression triggers autophagy in several human diseases. In …

Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative
disease with clinical characteristics of memory loss, dementia and cognitive impairment …