Previous studies have indicated that autophagy has an important function, not only in many
neurodegenerative diseases, but also in traumatic and ischemic brain injury. However, no …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

ABSTRACT LCN2/neutrophil gelatinase-associated lipocalin/24p3 (lipocalin 2) is a
secretory protein that acts as a mammalian bacteriostatic molecule. Under …

Proinflammatory stimuli, after amyloid β (Aβ) deposition, have been hypothesized to create a
self-reinforcing positive feedback loop that increases amyloidogenic processing of the Aβ …

The molecular mediators of cell death and inflammation in Alzheimer's disease (AD) have
yet to be fully elucidated. Caspase-8 is a critical regulator of several cell death and …

Although the essential genes for autophagy (Atg) have been identified, the molecular
mechanisms through which Atg proteins control 'self eating'in mammalian cells remain …

Macroautophagy is a major catabolic pathway that impacts cell survival, differentiation,
tumorigenesis, and neurodegeneration. Although bulk degradation sustains carbon sources …

Abstract The Vacuole Membrane Protein 1-VMP1-is a pancreatitis-associated
transmembrane protein whose expression triggers autophagy in several human diseases. In …

The recognition and clearance of dead cells is a process that must occur efficiently to
prevent an autoimmune or inflammatory response. Recently, a process was identified …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …