Previous studies have indicated that autophagy has an important function, not only in many
neurodegenerative diseases, but also in traumatic and ischemic brain injury. However, no …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular
degradative mechanisms that mediate the turnover of complementary repertoires of …

Autophagy is a stable self-sustaining process in eukaryotic cells. In this process, pathogens,
abnormal proteins, and organelles are encapsulated by a bilayer membrane to form …

Accumulating evidence has indicated that activation of microglia and neuroinflammation
reaction play a prominent role in Alzheimer's disease (AD). Inhibition of toll-like receptor 4 …

Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic
contents. It has been implicated in a variety of physiological and pathological conditions …

Autophagy is a process preserving the balance between synthesis, degradation and
recycling of cellular components and is therefore essential for neuronal survival and …

Background Neuroinflammation has an essential impact on the pathogenesis and
progression of Alzheimer's disease (AD). Mostly mediated by microglia and astrocytes …

Previous data demonstrate that traumatic brain injury (TBI) activates autophagy, and
increases microtubule-associated protein 1 light chain 3 (LC3) immunostaining mainly in …

In this issue of Neuron, Chakrabarty et al.(2015) and Guillot-Sestier et al.(2015) reveal that
the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive …